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Advanced Fertility guide

Intrauterine Insemination (IUI)

Who may benefit from IUI, how a cycle is monitored, success-limiting factors and the risk of multiple pregnancy.

Specialist-depth overview

Intrauterine insemination places prepared sperm into the uterus around ovulation. It can be useful in selected circumstances, but success depends strongly on age, diagnosis, sperm quality, tubal patency and whether medication is used.

At least one usable fallopian tube is generally required.
The number of cycles attempted should be based on age, diagnosis, response and opportunity cost.
Stimulation can increase the chance of multiple pregnancy, so follicle monitoring and cancellation criteria matter.

Who may be offered IUI

Possible indications include use of donor sperm, mild sperm-factor issues, ovulatory treatment or selected unexplained infertility. IUI is less effective when both tubes are blocked, sperm parameters are severely reduced or age-related decline makes delay important.

Cycle preparation

IUI may be performed in a natural cycle or with ovulation-induction medicines. Ultrasound and sometimes hormone testing track follicle development. The trigger and insemination timing are coordinated with ovulation.

Procedure and risks

Prepared sperm is passed through a thin catheter into the uterus. Cramping is usually brief. Infection is uncommon. The major treatment-related concern is multiple pregnancy when several follicles develop, so a cycle may be cancelled or converted according to an agreed policy.

Reviewing success and next steps

Success is assessed over several cycles rather than one attempt. After a defined number of unsuccessful cycles, the diagnosis and strategy should be reviewed rather than repeating treatment without a plan.

Questions worth discussing at your consultation

  • Why is IUI preferable to timed intercourse or IVF in my case?
  • How many follicles are acceptable before cancellation?
  • How many cycles are reasonable before reassessment?
  • What are the expected success rates for my age and diagnosis?
When to seek urgent careSeek urgent assessment after treatment for severe pain, heavy bleeding, fever, fainting or a positive pregnancy test with one-sided pain or bleeding.
Medical note: This page is educational and is structured to support a specialist consultation. Diagnosis, investigations and treatment must be individualised. It has not been presented as a substitute for an examination or emergency assessment.